Royal Air Force Typhoon jets have joined forces with French aircraft in a joint strike on an underground arms cache in Syrian territory used by the IS group, according to the UK's MoD.
The location, pinpointed through surveillance, was assessed as containing munitions and bombs, the statement said, and was positioned in mountains just to the north of the ancient city of Palmyra in central Syria.
"The RAF jets employed laser-guided Paveway IV weapons to strike a number of access tunnels leading to the facility... preliminary assessments are that the target was engaged successfully," officials stated.
There was no indication of any harm to civilians in the strike late on Saturday and every plane involved returned safely, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager refuelling tanker.
IS - referred to as ISIS - imposed militant control over large swathes of Iraq and Syria prior to its 2019 collapse.
"This strike underscores our UK leadership, and resolve to operate in unison with our allies, to eradicate any resurgence of the terrorist group and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the Defence Secretary said.
British military aircraft have conducted surveillance missions over Syrian airspace to "prevent any efforts to regroup" of the group subsequent to its military defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank all the members of the UK armed forces involved in this strike for their professionalism and their valour," the Defence Secretary commented. "They were among a great many British personnel on duty over the festive period. This operation, to take out dangerous terrorists who endanger our way of life, highlights how British military are ready to step up, all year round, protecting the UK domestically and powerful internationally."
During December, the United States armed forces conducted what it described as a "large-scale strike" on Islamic State objectives in the country, subsequent to an ambush claimed the lives of two US servicemembers and a civilian interpreter in Palmyra.
The UN says Islamic State still maintains roughly 5-7 thousand combatants in both countries.